ABSTRACT
BACKGROUND:
Mesenchymal
stem cels, underin vivo orin vitro specific induction conditions, can differentiate into the
cartilage,
muscle,
tendons and so on. Clinical trials concerning mesenchymal
stem cels mainly include
tissue repair (such as
bone,
cartilage and
joint repair) and
treatment of
heart,
liver,
spinal cord injury and
nervous system diseases.
OBJECTIVE:
To compare the
biological characteristics of mesenchymal
stem cels from different sources.
METHODS:
PubMed and CNKI databases were retrieved for articles related to sources of mesenchymal
stem cels and
biological characteristics of mesenchymal
stem cels published from 1987 to 2015. The retrieved articles were summarized and analyzed in the folowing aspects cel surface marker, proliferation, differentiation, migration, and function, so as to explore the merits and demerits of mesenchymal
stem cels from different sources. RESULTS AND
CONCLUSION:
A difference in the proliferation
ability and surface markers is found between different sources of mesenchymal
stem cels.
Immunological competence of mesenchymal
stem cels from different sources may be correlated with their activation status, species differences,
tissue sources and
culture conditions, resulting the
immunological competence of mesenchymal
stem cels from different sources is not exact the same. In-depth
understanding of the factors and mechanisms by which influence the migration of mesenchymal
stem cels from different sources can enhance the migration
ability of different sources of mesenchymal
stem cels, and increase their
efficiency in
wound healing,
tissue repair and
regeneration treatment.