Brain-targeted nasal drug delivery systems for the treatment of neurodegenerative diseases / 国际药学研究杂志

ABSTRACT

Incidence of neurodegenerative diseases has been increasing year by year in the current aging society which inter?feres the living quality of the patients severely. Pathological changes in neurodegenerative diseases appeare in central nervous system (CNS). The administration route of drugs to treat neurodegenerative diseases becomes a very important scientific research field. Part of drugs may cross over blood-brain barrier(BBB)to CNS by oral or injection administration. But most of drugs are distributed in the oth?er tissues and might cause adverse reactions ,such as gastrointestinal side-effects and arrhythmia. Moreover ,the compliance of the aging patients is poor. They cannot adhere to administer multi-dose drugs for sereral times a day. Nasal drug delivery systems could de?liver drugs to brains directly by nasal-brain route,avoiding BBB with high targeting ratio,high drug availability and good patients′compliance. The review summarizes the major types of neurodegenerative diseases and their current therapeutic methods. The impor?tant obstacles for brain-targeted drug delivery ,nose-brain routes and the factors influencing nasal absorption are introduced. More importantly,the principal formulations,recent research progress and the unsolved problems of brain-targeted nasal drug delivery sys?tems are also reviewed.