ABSTRACT
BACKGROUND:
Articular cartilage repair has been a difficulty in the clinical setting, which is mainly treated with autologous or al ogeneic osteochondral
grafts, and
cartilage periosteum or
periosteum grafts. However, the limited source,
secondary lesion and immunological rejection force some
researchers to search for a novel
treatment strategy,
cartilage tissue engineering, that is of great significance for
cartilage regeneration and repair.
OBJECTIVE:
To investigate the
tissue-engineered scaffolds for the repair of
articular cartilage defects.
METHODS:
The first author searched the
PubMed and WanFang databases for the articles addressing
tissue-engineered
cartilage for
articular cartilage defects published between 1991 and 2015 using the
keywords“
articular cartilage defect,
scaffold, tissue engineered
cartilage”in English and
Chinese, respectively. The irrelative and repetitive
literatures were excluded. RESULTS AND
CONCLUSION:
Final y 48 eligible
literatures were enrol ed based on the inclusion and exclusion criteria.
Cartilage tissue engineering possesses the advantages of control
ability, little damage to
tissue itself, and
biological repair of injured
cartilage.
Tissue-engineered scaffold material is a critical factor in
tissue engineering construction;therefore, it should hold biodegradability and
histocompatibility. The commonly used scaffold materials include natural macromolecule materials (col agen,
silk fibroin and
chitosan), and synthetic
polymer materials (polylactic
acid and tricalcium
phosphate). It is necessary to prepare composite scaffolds with high bioactivity integrate advantages of each material. The
tissue engineering is bound to be a hotspot in the field of
articular cartilage repair.