ABSTRACT
Objective:
To study the mechanism and effect of
Chinese medicine Yiqi Tongyang Huatan
prescription(益气通阳化痰方,YQTYHT) on
hyperlipidemia and
atherosclerosis(AS).
Methods:
The
rabbit′s model was established by
feeding the
food containing high
cholesterol,and 32
rabbits were randomly divided into four groups(each n=8) normal group,model group,Huoxue Huayu
prescription treatment group(活血化瘀方,HXHY group) and YQTYHT
treatment group(YQTYHT group).Before the experiment,at the end of 6 th and 12 th weeks after the experiment,the following items were measured
blood lipids platelet aggregation rate,
platelet adhesion rate,
malondialdehyde(MDA),
endothelin-1(ET-1),
nitric oxide(NO),the ratio of the
lipid plaque area and the thickness of the endothelial plaque.
Results:
After
feeding the
food containing high
cholesterol,the
blood lipids,
platelet aggregation rate,
platelet adhesion rate,MDA,ET1,the ratio of
lipid plaque area and the thickness of plaque were elevated significantly,while
serum NO3-/NO2-decreased significantly in model group.Compared with the model group,the
blood lipids were lower in the two
treatment groups,and the
blood lipid regulating effect in YQTYHT group was significantly better than that in HXHY group.
Platelet aggregation rate and
platelet adhesion rate of YQTYHT group and HXHY group were lower than those in the model group,but the degree of lowering in YQTYHT group and HXHY group had no significant differences.The
serum MDA of YQTYHT group and HXHY group was lower than that in model group,and the lowering effect in YQTYHT group was better than that in HXHY group.YQTYHT group and HXHY group had a significant increase on the level of
serum NO3-/NO2-and a decrease on the content of
plasma ET-1,furthermore,the effects in the former group were significantly better than those of the latter group.The area of
atherosclerotic plaque coverage in
aorta and the thickness of plaque of HXHY group were larger than those in YQTYHT group(both P