Optimization of breviscapin sustainded release tablets by mixture uniform design / 中成药
Chinese Traditional Patent Medicine
; (12)1992.
Article
在 Zh
| WPRIM
| ID: wpr-575259
Responsible library:
WPRO
ABSTRACT
AIM: To optimize the excipient formulation of lactose,HPMC_(SH4000) and Carbopol 71 G in breviscapin sustained release tablets by mixture uniform design. METHODS: Different formulations,single factor f_2 and multifactors of cumulative release as index,were evaluated respectively. RESULTS: The optical formulations obtained by the two methods were identical,and the tablets with optical formulation had ideal sustained release. CONCLUSION: Mixture uniform design is simple,direct and uniform.It can be used in optimization of formulation with invariable amount.