Effect of Danchi Capsule on the Changes of Cytokine and Cell Activity of Cell Supernatant of Eutopic Endometrium in Patients with Endometriosis / 中国中医药信息杂志

ABSTRACT

Objective To reaserch the effect of Danchi capsule on the changes of monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-? (TNF-?) and solution intercellular adhesion molecule-1 (sICAM-1) of cell supernatant of eutopic endometrium in patients with edndometriosis. Methods Cells were divied into five groupsDanchi large, medium, small dosage group, blank group and dannazol group in control, detected by ELISA method and MTT method. To observe the levels of MCP-1, TNF-?and sICAM-1 of eutopic endometrial cells and cell activity. Results The group of DanChi large dosage decreased significantly the level of TNF-?, the group of Danchi large and medium dosage decreased the level of MCP-1 significantly. Conclusion Danchi capsule may descend and inhibite the production and activity of these cytokines which involved in three steps: adhesion and implantation-angiogenesis-progression and infiltration, then inhibit adhesion and implantation of endometrial cells.