Role of mitochondrial damage and repair in Parkinson′s disease / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 906-909,910, 2015.
Article
在 Zh
| WPRIM
| ID: wpr-600609
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ABSTRACT
Parkinson’ s disease ( PD) is a common disease in central nervous system, for which an effective treatment has yet to be found. The causes of PD include genetic, environmental, aging factors, etc. There is a common factor which can lead to the degeneration of dopaminergic neurons in the substantiamito-chondrial damage and repair. This paper has summarized the en-vironmental and genetic factors that can cause mitochondrial damage in dopaminergic neurons, and outlined several mitochon-drial repairing pathways ( such as mitophagy) in the treatment of PD. It also analyzes the research situation of utilizing natural medicine in the therapy of PD from the perspective of the mito-chondrial protection.