Preventive Effect of Fosfomycin on Cisplatin Induced Ototoxicity in Cochlea of Guinea Pig / 대한이비인후과학회지

ABSTRACT

BACKGROUND AND OBJECTIVES: The use of cisplatin as a therapeutic drug in malignant neoplasm is known to have associated side effects such as nephrotoxicity and ototoxicity. Although the nephrotoxic effect of this drug can be somewhat decreased by use of the hydration method, prevention of the ototoxic effect, which is known to induce irreversible change on the cochlea, has not been well established. The purose of this study is to evaluate the preventive effect of fosfomycin in cisplatin induced ototoxicity. METHODS: Fosfomycin was used to reduce the ototoxic effects of cisplatin, and its efficacies were evaluated anatomically as well as physiologically. Anatomically, a histologic study of cochleas was carried out by scanning electro-microscopy, and physiologically, cochlear microphonics and compound action potentials were studied in guinea pigs. RESULTS: Protection against distortion and loss of outer hair cells in the basal turn of cochlea caused by cisplatin was found to be statistically significant in the groups injected with fosfomycin. CONCLUSION: Fosfomycin was found to be effective in providing protection against cisplatin induced ototoxicity.