ABSTRACT
Objective:
To clarify correlation between
lipoprotein subfraction and different age of
coronary heart disease.
Methods:
A total of 1217
patients with
coronary angiography (CAG) confirmed CAD were consecutively enrolled. According to
onset age, the
patients were divided into 3 groups Very early CAD group, n=135
patients, ≤45 years, Early CAD group, n=505
patients,
male at (45-55) years and
female at (45-65) years, Late CAD group, n=577
patients,
male>55 years and
female>65 years. Meanwhile, there was a
Control group, n=72 subjects, ≤45 years with normal CAG. The
Lipoprotein system was used to classify
lipoprotein subfractions and to analyze the distributions of different particles of
high-density lipoprotein (HDL) subfraction and
low-density lipoprotein (LDL) subfraction in above 4 groups; to explore the relationship between HDL subfraction and very early CAD occurrence.
Results:
Compared with other groups, Very early CAD group had decreased large particle of HDL subfraction and increased small particle of LDL subfraction, P<0.05.
Logistic regression analysis found that the large particle of HDL subfraction was negatively related to very early CAD occurrence (OR=0.872, 95% CI 0.825-0.922), small particle of LDL subfraction was positively related to very early CAD occurrence (OR=1.038, 95% CI 1.008-1.069). Further multivariate
Logistic regression analysis indicated that only large particle of HDL subfraction was obviously negatively related to very early CAD occurrence (OR=0.899, 95% CI 0.848-0.954).
Conclusion:
Large particle of HDL subfraction was negatively related to very early CAD occurrence which implied it played an important
role in very early CAD process.