Follicular fluid cerebellin and betatrophin regulate the metabolic functions of growing follicles in polycystic ovary syndrome / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
; : 33-39, 2017.
Article
在 En
| WPRIM
| ID: wpr-66668
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
The aim of this study was to assess the changes of follicular fluid (FF) and serum levels of cerebellin precursor protein 1 (cbln1) and betatrophin in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) with a gonadotropin-releasing hormone (GnRH) antagonist protocol.METHODS:
Twenty infertile women with PCOS and 20 control women diagnosed as poor responders undergoing ovarian stimulation with a GnRH antagonist were included. Blood samples were obtained during ovum pick-up. Follicular fluid from a dominant follicle was collected from the subjects. Using enzyme-linked immunosorbent assays, FF and serum levels of cbln1 and betatrophin were measured in both groups of participants. Metabolic and hormonal parameters were also determined and correlated with each other.RESULTS:
Both groups of women had similar serum and FF betatrophin levels (55.0±8.9 ng/mL vs. 53.1±10.3 ng/mL, p=0.11). The serum and FF betatrophin levels of poor responders were found to be similar (49.9±5.9 ng/mL vs. 48.9±10.7 ng/mL, p=0.22). Conversely, the FF cbln1 levels of PCOS women were found to be significantly higher than the serum cbln1 levels (589.1±147.6 ng/L vs. 531.7±74.3 ng/L, p<0.02). The FF cbln1 levels of control participants without PCOS were significantly higher than their serum cbln1 levels (599.3±211.5 ng/L vs. 525.3±87.0 ng/L, p=0.01). Positive correlations were detected among body mass index, insulin resistance, serum insulin, total testosterone, and betatrophin levels in the PCOS group.CONCLUSION:
Follicular fluid betatrophin and cbln1 concentrations may play a pivotal role on follicular growth in PCOS subjects undergoing IVF/ICSI with an antagonist protocol.Key words
全文:
1
索引:
WPRIM
主要主题:
Ovulation Induction
/
Ovum
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Polycystic Ovary Syndrome
/
Spermatozoa
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Testosterone
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In Vitro Techniques
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Insulin Resistance
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Enzyme-Linked Immunosorbent Assay
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Fertilization in Vitro
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Body Mass Index
研究类型:
Guideline
限制:
Female
/
Humans
语言:
En
期刊:
Clinical and Experimental Reproductive Medicine
年:
2017
类型:
Article