Experimental study on bioactive membrane for guided bone regeneration in alveolar cleft / 实用口腔医学杂志

ABSTRACT

Objective: To evaluate the effect of barrier m em brane on guided bone regeneration(GBR) in alveolar cleft. Methods: The alveolar cleft of animal model was established in the maxilla in 10 rabbi ts. The artificial alveolar clefts were treated immediately with following mater ials respectively: (1) PLA+collagen+rhBMP-2 membrane, (2)PLA membrane, (3)colla ge membrane, (4) blank control. All the membranes were fixed by PLA pin and mini -titanium pin. The animals were sacrificed 2 weeks, 1,2,3 and 6 months after su rgery respectively. Samples were studied through macroscopic observation, X-rad iography, histomorphology and enzyme histochemistry analysis. Results: In the clefts covered with the 3 kinds of membrane more bone fromation wa s observed. The compound membrane of PLA+collagen+rhBMP-2 showed the best bone regeneration effects. Conclusion: The GBR technique can be used to repair the bone defect of alveolar cleft.