An experiment on ectopia osteogenesis of rhBMP-2/nHA/Co compound membrane / 实用口腔医学杂志

ABSTRACT

Objective:To evaluate the ectopia osteogenesis ability of rhBMP-2/nHA/Co compound membrane.Methods:Two membranes were fabricated(1) nHA/Co group(2) rhBMP-2/nHA/Co group.Both of them was evaluated after implantation under thigh muscle of nude mice for 10,20,30 days.Results:More bone-like structures in rhBMP-2/nHA/Co group were found,than that in nHA/Co group.Conclusion:Collagen and nano-HA are suitable sustained release systems for rhBMP-2 in animal experiment and the rhBMP-2/nHA/Co compound membrane can effectively induce ectopia osteogenesis.