Epigenetic regulation of epithelial-mesenchymal transition / 国际肿瘤学杂志

ABSTRACT

The hallmark of epithelial-mesenchymal transition (EMT) is the loss of E-cadherin.The downregulation of E-cadherin can be mediated by its transcriptional repression through the binding of EMT transcription factors to the E-cadherin promoter.Epigenetic mechanisms including DNA methylation,histone code and microRNAs are involved in the regulation of EMT-related genes.Studies have shown that EMT transcription factors can cooperate with several epigenetic modifiers to participate in the expression of E-cadherin.Targeting epigenetic regulation of EMT represents a new promising therapeutic direction.