ABSTRACT
Objective:
To analyze influence of Danhong
injection combined
metoprolol tartrate on
hemodynamics and
ECG in
patients with
coronary heart disease (CHD) and arrhythmias .
Methods:
A total of 98 CHD
patients with ar-rhythmias treated in our
hospital from Feb 2013 to Sep 2016 were selected .The
patients were randomly divided into routine
treatment group and combined
treatment group (received Danhong
injection combined
metoprolol tartrate based on routine
treatment group ) ,both groups were treated for continuous four weeks .
Blood pressure etc .indexes and
therapeutic effect were observed and compared between two groups before and
after treatment .
Results:
Com-pared with before
treatment ,after four-week
treatment ,there were significant reductions in systolic
blood pressure (SBP) ,diastolic
blood pressure (DBP) ,
mean arterial pressure (MAP) ,times of non-sustained ventricular tachycar-dia (NSVT) and ventricular
premature beat (VPB) ,
erythrocyte sedimentation rate (ESR) ,
fibrinogen (Fg) ,hem-atocrit (HCT) ,whole
blood low shear
viscosity (NBL) and whole
blood high shear
viscosity (NBH) ,and significant rise in PR interval in two groups ,and significant rise in QT interval in combined
treatment group , P<0. 05 or <0.01. Compared with routine
treatment group after four-week
treatment ,there were significant reductions in levels of SBP [ (120.11 ± 10.23) mmHg vs.(108.11 ± 7.83) mmHg] ,DBP [ (85.61 ± 5.61) mmHg vs.(70.12 ± 4.12) mmHg] ,MAP [ (100.11 ± 7.23) mmHg vs .(81.33 ± 5.16) mmHg] ,times of NSVT [ (4.51 ± 0.31) times/d vs. (2.11 ± 0.25) times/d] and VPB [ (3673.11 ± 86.34) times/d vs.(2711.34 ± 62.31) times/d] ,ESR [ (19.72 ± 2.73) mm/h vs.(12.44 ± 1.98) mm/h] ,Fg [ (300.11 ± 23.44) g/L vs.(223.43 ± 16.74) g/L] ,HCT [ (40.12 ± 3.57)% vs.(31.32 ± 2.14)% ] ,NBL [ (8.22 ± 1.11) mpa·s vs .(6.72 ± 0.84) mpa·s] and NBH [ (5.12 ± 0.73) mpa·s vs .(3.98 ± 0.56) mpa·s] ,and significant rise in QT interval [ (0.38 ± 0.17) s vs .(0.49 ± 0.19) s] ,PR interval [ (0.17 ± 0.02) s vs.(0.19 ± 0.03) s] and QRS interval [ (0.07 ± 0.02) s vs.(0.09 ± 0.03) s] in combined
treatment group , P<0. 01 all.Total effective rate of combined
treatment group was significantly higher than that of routine
treatment group (89.80% vs.73.47%) , P=0.035 .
Conclusion:
Danhong
injection combined
metoprolol tartrate can significantly improve
hemodynamic and
ECG indexes in CHD
patients with arrhythmias , which is worth extending .