ABSTRACT
Objectives:
This study sought to compare both the
safety and
efficacy of transradial (TRI) versus transfemoral (TFI) approach in
women undergoing
percutaneous coronary intervention (PCI) in
China.
Methods:
We retrospectively analyzed data from 5 067
women undergoing PCI in Fuwai
Hospital,
Beijing,
China between 2006 and 2011. 4 105
patients underwent TRI and 962
patients underwent TFI. A One-to-one
propensity score matching (PSM) was performed to control for potential
biases. A total of 897 pairs were matched.
Results:
After controlling for confounders using PSM, baseline and procedural characteristics were well-balanced between TRI and TFI groups.
Patients undergoing TRI had significantly fewer major post-PCI
bleeding (1.0% vs 3.5%, P<0.001) and access site
complications (8.5% vs 19.7%,P<0.001) after PSM. There was no statistical differences in the
incidence rates of
major adverse cardiac events (a composite of
cardiac death,
myocardial infarction, and target vessel revascularization) during
hospitalization (P>0.05). Multiple
logistic regression analysis showed that TRI was an independent predictor of reduced major
bleeding (OR=0.64, 95%CI 0.54-0.76, P<0.001) and access site
complications (OR=0.67, 95%CI0.61-0.74, P<0.001).
Conclusions:
Our result show that TRI is related to reduced major
bleeding and access site
complications as compared to TFI in
Chinese female patients undergoing PCI.