ABSTRACT
OBJECTIVE:
To investigate
clinical efficacy of Sofren
injection combined with Vinpocetine
injection in the
treatment of acute massive
cerebral infarction,and its effects on hemorheological indexes and
serum NOS.
METHODS:
A total of 60
patients with acute massive
cerebral infarction in our
hospital during Jan.2014-Jun.2016 were selected as
research objects and divided into trial group and
control group according to random number table,with 30 cases in each group.
Control group was given
Citicoline injection 0.5 g,ivgtt,qd.Trial group was additionally given Vinpocetine
injection 20 mg added into 0.9%
Sodium chloride injection 250 mL,ivgtt,qd;1 h later washing tube,they were given Sofren
injection 10 mL added into 0.9%
Sodium chloride injection 250 mL,ivgtt,for consecutive 14 d.Clinical efficacies and
safety of 2 groups were observed,and hemorheological indexes and NOS levels were observed before and
after treatment.
RESULTS:
The total response rate (83.33%)of trial group was significantly higher than that (50.00%) of
control group,with statistical significance (P<0.05).Before
treatment,there was no statistical significance in hemorheological indexes or
serum NOS levels between 2 groups (P>0.05).
After treatment,hemorheological indexes of 2 groups were decreased significantly,and the trial group was significantly lower than the
control group.The level of
serum NOS in 2 groups were increased significantly,and the trial group was significantly higher than the
control group,with statistical significance (P<0.05).No obvious ADR was found in 2 groups.
CONCLUSIONS:
Sofren
injection combined with Vinpocetine
injection show significant
therapeutic efficacy for acute massive
cerebral infarction,can reduce
blood viscosity and increase
blood perfusion with good
safety.