ABSTRACT
Objective:
To observe the intervention effect of
acarbose on cerebral arterial
thrombosis complicated with impaired glu-cose tolerance(IGT).
Methods:
Totally 120 cases of IGT
patients with
ischemic stroke were randomly divided into the
observation group (58 cases) and the
control group(62 cases). The two groups were given the same basic
treatment,while the
observation group was treated with
acarbose 50 mg,po,tid for 3 months additionally. Before and after the
treatment,the levels of
blood lipid and
blood glucose,
serum high-
sensitivity C reactive protein(
hsCRP) and
carotid intima media thickness(IMT) and the other adverse
drug reac-tions were detected in the two groups. After 6-month follow-up,the new
incidence of IGT was compared between the groups.
Results:
After the
treatment,2 hPG,HbAlc,
hsCRP and the other
indicators in the
observation group were significantly improved when com-pared with those before the
treatment(P<0.01 or P<0.05),while only
hsCRP in the
control group was significantly improved when compared with that before the
treatment(P<0.05) and that in the
observation group. 2 hPG,HbAlc,
hsCRP,IMT and the other in-dicators in the
observation group were significantly better than those in the
control group(P<0.01 or P<0.05). There was no signifi-cant change in the level of
blood lipid in the two groups. There was no
adverse drug reaction during the
treatment. After the 6-month follow-up,the new
incidence of IGT in the
observation group was 1.82%,which was significantly lower than that in the
control group (7.27%,P<0.05).
Conclusion:
Among the
patients with cerebral arterial
thrombosis complicated with
impaired glucose tolerance, the normal
treatment measures plus
acarbose can effectively delay
carotid artery IMT incrassation and decrease the
risk of cardiovascular events
recurrence with better relative
safety.