ABSTRACT
Objective:
To investigate the clinical value of ambulatory
electrocardiogram and the
neutrophils to
lymphocytes ratio (NLR) in the
diagnosis on
Kawasaki disease combined with changes of
coronary artery for
children.
Methods:
80
children with
Kawasaki disease were enrolled in the
research. According to the combined situation of
coronary artery disease, all of
children with combined
coronary artery disease were divided in
observation group (48 cases) and the
children without combined
coronary artery disease were divided in
control group (32 cases). All of
children received the examinations of dynamic
electrocardiogram, routine
electrocardiogram, ultrasound cardiogram scan and
blood routine
detection within 15d of occurring
disease. And the amounts of
neutrophil and
lymphocyte, and change of dynamic
electrocardiogram of all of
children were recorded and analyzed. And then the amounts of
neutrophil and
lymphocyte and the NLR of the two groups were further compared.
Results:
The
sinus tachycardia,
atrioventricular block, abnormal average
heart rate and the proportions of total abnormal number of
observation group were significantly higher than that of
control group, and the difference of total number of ambulatory electrocardiographic abnormality between the two groups were significant (x2=20.112, P<0.05). The results of ambulatory
electrocardiogram for
Kawasaki disease combined with abnormal
coronary artery were significantly higher than that of
control group (x2=17.778, P<0.05). Compared with
control group, the
coronary artery ectasia was more larger, the amount of
neutrophils would be more greater in
observation group, and the difference between the two groups was significant (t=-3.464, P<0.05). Besides, the difference of NLR between
patients with mild
ectasia of
observation group and
patients of
control group was significantly (t=2.976, P<0.05).
Conclusion:
Dynamic
electrocardiogram and the NLR have important significance in the
diagnosis for
children with
Kawasaki disease combined with the change of
coronary artery.