Is Clostridium difficile infection a real threat in patients with ulcerative colitis? A prospective, multicenter study in Korea
Intestinal Research
; : 267-272, 2018.
Article
在 En
| WPRIM
| ID: wpr-714184
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS: Clostridium difficile infection (CDI) has been reported to be a cause of flare-ups in patients with ulcerative colitis (UC). We evaluated the prevalence and clinical outcomes of CDI in patients with UC hospitalized for flare-ups. METHODS: This was a prospective, multicenter study including 7 academic teaching hospitals in Korea. All consecutive patients with UC admitted for disease flare-up were enrolled. We detected the presence of CDI by using enzyme immunoassay, real-time polymerase chain reaction (RT-PCR) for toxin genes, and sigmoidoscopy. RESULTS: Eighty-one consecutive patients with UC were enrolled from January 2014 to December 2015. Among 81 patients, 8 (9.9%) were diagnosed with CDI. Most of the cases were identified by RT-PCR. Enzyme immunoassay was positive in 3 of 8 patients, and only 1 had typical endoscopic findings of pseudomembranous colitis. There were no differences in demographic data, length of hospital stay, or colectomy rate between patients with and without CDI. CONCLUSIONS: CDI was not a rare cause of flare-up in patients with UC in Korea. However, CDI did not appear to affect the course of UC flare-up in Korean patients. RT-PCR was sensitive in detecting CDI and can be considered a diagnostic tool in patients with UC flare-up.
Key words
全文:
1
索引:
WPRIM
主要主题:
Ulcer
/
Enterocolitis, Pseudomembranous
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Colitis, Ulcerative
/
Polymerase Chain Reaction
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Prevalence
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Prospective Studies
/
Clostridioides difficile
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Immunoenzyme Techniques
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Sigmoidoscopy
/
Clostridium
研究类型:
Clinical_trials
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Observational_studies
/
Prevalence_studies
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Prognostic_studies
/
Risk_factors_studies
限制:
Humans
国家/地区名称主题:
Asia
语言:
En
期刊:
Intestinal Research
年:
2018
类型:
Article