Clinical features of recently diagnosed papillary thyroid carcinoma in elderly patients aged 65 and older based on 10 years of sonographic experience at a single institution in Korea
Ultrasonography
; : 355-362, 2017.
Article
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| WPRIM
| ID: wpr-731014
Responsible library:
WPRO
ABSTRACT
PURPOSE:
The aim of this study was to assess the characteristics of papillary thyroid carcinoma (PTC) in patients aged 65 and older in order to predict postoperative recurrence based on the results of ultrasonographic surveillance.METHODS:
Among 1,494 patients (200 male and 1,294 female; mean age, 46.6±11.3 years) who underwent surgery for thyroid cancer at our institution between 2006 and 2015, we retrospectively enrolled 150 PTC patients (29 male and 121 female; mean age, 69.4±4.2 years). To identify the risk factors for recurrence, we analyzed age, gender, multiplicity, size, number, extrathyroidal extension (ETE) of the tumor, lymph node metastasis (LNM), type of surgery, and the dose of radioactive ablation using a Cox regression model to identify hazard ratios (HRs).RESULTS:
Among the 115 asymptomatic patients with PTCs detected by screening ultrasonography (n=86), other cross-sectional imaging modalities (computed tomography or positron emission tomography-computed tomography, n=13), or incidentally through a surgical specimen (n=16), 78 patients were confirmed to have papillary thyroid microcarcinomas (PTMCs). The other 35 patients presented with palpable neck masses (n=25), vocal cord palsy (n=9) or blood-tinged sputum (n=1). During the follow-up period (mean, 43.6 months), 17 patients (12.5%) experienced recurrence in the neck. None of the patients died due to PTC-related recurrence or distant metastasis during the follow-up period. Cox regression analysis demonstrated that tumor size (HR, 2.12; P<0.001) and LNM (central LNM HR, 9.08; P=0.004; lateral LNM HR, 14.71; P=0.002; both central and lateral LNM HR, 58.41; P<0.001) significantly increased the recurrence rate. ETE, LNM, and recurrence were significantly less frequent in PTMCs than in non-PTMC (all P<0.001).CONCLUSION:
PTCs of small size and absent LNM showed significantly better prognoses in patients 65 years and older.Key words
全文:
1
索引:
WPRIM
主要主题:
Prognosis
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Recurrence
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Sputum
/
Thyroid Gland
/
Thyroid Neoplasms
/
Vocal Cord Paralysis
/
Mass Screening
/
Retrospective Studies
/
Risk Factors
/
Follow-Up Studies
研究类型:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
限制:
Aged
/
Female
/
Humans
/
Male
国家/地区名称主题:
Asia
语言:
En
期刊:
Ultrasonography
年:
2017
类型:
Article