Evaluation of a polyurethane foam dressing impregnated with 3% povidone-iodine (Betafoam) in a rat wound model
Annals of Surgical Treatment and Research
; : 1-7, 2018.
Article
在 En
| WPRIM
| ID: wpr-739554
Responsible library:
WPRO
ABSTRACT
PURPOSE: The purpose of this study was to evaluate the efficacy of Betafoam in terms of wound healing and safety. METHODS: Fifty-four male adult Sprague-Dawley rats (weight, 200–250 g) were used in the study. Full-thickness skin defects were created on the back of each rats. The rats were assigned to 6 groups according to the type of wound dressing used (n = 9 for each group): Betafoam, Allevyn-Ag, Mepilex-Ag, Medifoam silver, Polymem-Ag, and gauze. The wound size, histological findings, and amount of DNA on the changed dressings for each group were analyzed and compared. RESULTS: All groups showed an effective decrease in wound size. However, the differences between Betafoam and the other dressings were statistically significant on day 14 (P < 0.05). The number of newly generated blood vessels in the Betafoam group was significantly higher than in the gauze, Allevyn-Ag, and Medifoam silver groups (P < 0.001). In the Betafoam group, the proportion of collagen deposition was highest and showed a significantly superior arrangement of collagen fibers compared with the gauze, Allevyn-Ag, Mepilex-Ag, and Medifoam silver groups. The total content of the remaining DNA counts of the exchanged dressings were significantly lower in the Betafoam group than the others. CONCLUSION: Betafoam is effective in wound healing and provides the best performance amongst the various types of dressing materials in terms of re-epithelialization, angiogenesis, collagen deposition, and tissue invasion.
Key words
全文:
1
索引:
WPRIM
主要主题:
Polyurethanes
/
Povidone-Iodine
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Silver
/
Skin
/
Bandages
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Wound Healing
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Wounds and Injuries
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Blood Vessels
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DNA
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Collagen
研究类型:
Prognostic_studies
限制:
Animals
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Humans
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Male
语言:
En
期刊:
Annals of Surgical Treatment and Research
年:
2018
类型:
Article