Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques
The World Journal of Men's Health
; : 148-156, 2019.
Article
在 En
| WPRIM
| ID: wpr-742363
Responsible library:
WPRO
ABSTRACT
During the last decades the study of male infertility and the introduction of the assisted reproductive techniques (ARTs) has allowed to understand that normal sperm parameters do not always predict fertilization. Sperm genetic components could play an important role in the early stages of embryonic development. Based on these acquisitions, several epigenetic investigations have been developed on spermatozoa, with the aim of understanding the multifactorial etiology of male infertility and of showing whether embryonic development may be influenced by sperm epigenetic abnormalities. This article reviews the possible epigenetic modifications of spermatozoa and their effects on male fertility, embryonic development and ART outcome. It focuses mainly on sperm DNA methylation, chromatin remodeling, histone modifications and RNAs.
Key words
全文:
1
索引:
WPRIM
主要主题:
Spermatozoa
/
RNA
/
DNA Methylation
/
Reproductive Techniques, Assisted
/
Chromatin Assembly and Disassembly
/
Histone Code
/
Embryonic Development
/
Fertility
/
Fertilization
/
Epigenomics
研究类型:
Prognostic_studies
限制:
Female
/
Humans
/
Male
/
Pregnancy
语言:
En
期刊:
The World Journal of Men's Health
年:
2019
类型:
Article