Association between Helicobacter pylori Infection and Cerebral Small Vessel Disease / 가정의학회지
Korean Journal of Family Medicine
; : 227-232, 2015.
Article
在 En
| WPRIM
| ID: wpr-7565
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Small vessel disease is an important cause of cerebrovascular diseases and cognitive impairment in the elderly. There have been conflicting results regarding the relationship between Helicobacter pylori infection and ischemic stroke. This study aimed to examine the association between H. pylori infection and cerebral small vessel disease.METHODS:
The study included 1,117 patients who underwent brain magnetic resonance imaging and H. pylori identification between 2005 and 2013 at Health Promotion Center, Seoul National University Hospital. Multivariable logistic regression analysis was used to assess the association between H. pylori infection and small vessel disease with adjustment for age, sex, hypertension, diabetes mellitus, dyslipidemia, body mass index, smoking status, problem drinking, and antiplatelet use.RESULTS:
The adjusted odds ratios (aORs) for the association between H. pylori infection and silent brain infarction and cerebral microbleeds were 1.03 (95% confidence interval [CI], 0.66-1.61) and 0.70 (95% CI, 0.38-1.28), respectively. The aORs for silent brain infarction and cerebral microbleeds were 0.81 (95% CI, 0.44-1.44) and 0.59 (95% CI, 0.30-1.18) in patients aged 65 years, respectively. Moreover, the aORs for silent brain infarction and cerebral microbleeds were 0.96 (95% CI, 0.54-1.71) and 0.74 (95% CI, 0.33-1.69) in H. pylori-infected patients without atrophic gastritis and 0.89 (95% CI, 0.48-1.62) and 0.99 (95% CI, 0.43-2.27) in those with atrophic gastritis, respectively.CONCLUSION:
No association between H. pylori infection and small vessel disease was observed. H. pylori-induced inflammation may not be a risk factor for microcirculatory damage in the brain.Key words
全文:
1
索引:
WPRIM
主要主题:
Smoke
/
Brain
/
Magnetic Resonance Imaging
/
Smoking
/
Body Mass Index
/
Logistic Models
/
Odds Ratio
/
Risk Factors
/
Helicobacter pylori
/
Helicobacter
研究类型:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
限制:
Aged
/
Humans
国家/地区名称主题:
Asia
语言:
En
期刊:
Korean Journal of Family Medicine
年:
2015
类型:
Article