Efficacy and tolerability of adjunctive perampanel treatment in children under 12 years of age with refractory epilepsy / 소아과
Korean Journal of Pediatrics
; : 269-273, 2019.
Article
在 En
| WPRIM
| ID: wpr-760219
Responsible library:
WPRO
ABSTRACT
PURPOSE:
There is limited data on the use of perampanel in children under 12 years of age. We evaluated the efficacy and tolerability of adjunctive perampanel treatment in children under 12 years of age with refractory epilepsy.METHODS:
This retrospective observational study was performed in Kyungpook National University Hospital from July 2016 to March 2018. A responder was defined as a patient with ≥50% reduction in monthly seizure frequency compared with the baseline. Adverse events and discontinuation data were obtained to evaluate tolerability.RESULTS:
Twenty-two patients (8 males, 14 females) aged 3.1–11.4 years (mean, 8.0±2.5 years) were included in this study. After an average of 9.2 months (range, 0.5–19 months) of follow-up, 15 patients (68%) showed a reduction in seizure frequency, including 5 patients (23%) with seizure freedom. The age at epilepsy onset was significantly lower (P=0.048), and the duration of epilepsy was significantly longer (P=0.019) in responders than in nonresponders. Nine patients (41%) experienced adverse events, including somnolence (23%), respiratory depression (9%), violence (4.5%), and seizure aggravation (4.5%). The most serious adverse event was respiratory depression, which required mechanical ventilation in 2 patients (9%). Eight patients (36%) discontinued perampanel due to lack of efficacy or adverse events. Three out of 4 patients (75%) who discontinued perampanel due to adverse events had an underlying medical condition.CONCLUSION:
Perampanel offers a treatment option for refractory epilepsy in children. Adjunctive treatment with perampanel requires special consideration in those with underlying medical conditions to prevent serious adverse events.Key words
全文:
1
索引:
WPRIM
主要主题:
Respiration, Artificial
/
Respiratory Insufficiency
/
Seizures
/
Violence
/
Retrospective Studies
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Follow-Up Studies
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Epilepsy
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Observational Study
/
Freedom
研究类型:
Observational_studies
/
Prognostic_studies
限制:
Child
/
Humans
/
Male
语言:
En
期刊:
Korean Journal of Pediatrics
年:
2019
类型:
Article