Nasal eosinophilia and eosinophil peroxidase in children and adolescents with rhinitis / 소아과
Korean Journal of Pediatrics
; : 353-359, 2019.
Article
在 En
| WPRIM
| ID: wpr-760234
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Researchers have shown that eosinophil peroxidase (EPO) is a relatively accurate marker of eosinophilia and eosinophil activity. However, its use as a marker of eosinophilic inflammation in nasal secretions is limited because the diagnostic cutoff values of EPO for use as a one-time test for allergic diseases such as allergic rhinitis have not been established.PURPOSE:
To identify the correlation between nasal eosinophil count and EPO in children and adolescents with rhinitis.METHODS:
We recruited patients <18 years of age with rhinitis for more than 2 weeks or more than 2 episodes a year whose nasal eosinophil and EPO were measured at a single allergy clinic. The eosinophil percentage was calculated by dividing the eosinophil count by the number of total cells under light microscopy at ×1,000 magnification. EPO and protein were measured from nasal secretions. We retrospectively analyzed the correlation between nasal eosinophils and protein-corrected EPO (EPO/protein) value.RESULTS:
Of the 67 patients enrolled, 41 were male (61.2%); the mean age was 8.2±4.0 years. The median nasal eosinophil count was 1 and percentage was 1%. The median protein-corrected EPO value was 12.5 ng/μg (range, 0–31 ng/μg). There was a statistically significant correlation between eosinophil count and percentage (P<0.001). However, the eosinophil percentage and EPO did not correlate. The eosinophil count and EPO had a statistically significant correlation (P =0.01). The EPO cutoff value examined for nasal eosinophil counts of 2, 5, 10, and 20 was 17.57 ng/μg regardless of the reference count. The largest area under the curve value was obtained when the receiver operating characteristic curve was drawn using the eosinophil count of 2.CONCLUSION:
Nasal eosinophil count was significantly associated with protein-corrected EPO.Key words
全文:
1
索引:
WPRIM
主要主题:
Rhinitis
/
Retrospective Studies
/
ROC Curve
/
Eosinophil Peroxidase
/
Eosinophilia
/
Eosinophils
/
Rhinitis, Allergic
/
Hypersensitivity
/
Inflammation
/
Microscopy
研究类型:
Observational_studies
/
Prognostic_studies
限制:
Adolescent
/
Child
/
Humans
/
Male
语言:
En
期刊:
Korean Journal of Pediatrics
年:
2019
类型:
Article