Prognostic Role and Clinical Association of Tumor-Infiltrating Lymphocyte, Programmed Death Ligand-1 Expression with Neutrophil-Lymphocyte Ratio in Locally Advanced Triple-Negative Breast Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 649-663, 2019.
Article
在 En
| WPRIM
| ID: wpr-763130
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Tumor-infiltrating lymphocyte (TIL), programmed death-ligand 1 (PD-L1) expression and neutrophil-to-lymphocyte ratio (NLR) is associated to immunogenicity and prognosis of breast cancer. We analyzed baseline NLR, changes of NLR, TIL, and PD-L1 during neoadjuvant chemotherapy (NAC) and their clinical implication in triple-negative breast cancer (TNBC). MATERIALS ANDMETHODS:
Between January 2008 to December 2015, 358 TNBC patients were analyzed. Baseline NLR, 50 paired NLR (initial diagnosis, after completion of NAC) and 34 paired tissues (initial diagnosis, surgical specimen after completion of NAC) were collected. Changes of TIL, CD4, CD8, forkhead box P3 (FOXP3), and PD-L1 expression were assessed with immunohistochemical stain.RESULTS:
Low NLR (≤ 3.16) was associated to superior survival (overall survival 41.83 months vs. 36.5 months, p=0.002; disease-free survival [DFS] 37.85 months vs. 32.14 months, p=0.032). Modest NLR change after NAC (–30% < NLR change < 100%) showed prolonged DFS (38.37 months vs. 22.37 months, p=0.015). During NAC, negative or negative conversion of tumor PD-L1 expression was associated to poor DFS (34.77 months vs. 16.03 months, p=0.037), and same or increased TIL showed trends for superior DFS, but without statistical significance. Positive tumor PD-L1 expression (H-score ≥ 5) in baseline or post-NAC tissue was associated to superior DFS (57.6 months vs. 12.5 months, p=0.001 and 53.3 months vs. 18.9 months, p=0.040). Positive stromal PD-L1 expression in baseline was also associated to superior DFS (50.2 months vs. 20.4 months, p=0.002).CONCLUSION:
In locally advanced TNBC, baseline NLR, changes of NLR during NAC was associated to survival. Baseline PD-L1 expression and changes of PD-L1 expression in tumor tissue during NAC also showed association to prognosis.Key words
全文:
1
索引:
WPRIM
主要主题:
Prognosis
/
Breast Neoplasms
/
Lymphocytes, Tumor-Infiltrating
/
Disease-Free Survival
/
Diagnosis
/
Drug Therapy
/
Triple Negative Breast Neoplasms
研究类型:
Diagnostic_studies
/
Prognostic_studies
限制:
Humans
语言:
En
期刊:
Cancer Research and Treatment
年:
2019
类型:
Article