Scopariusols L-T, nine new ent-kaurane diterpenoids isolated from Isodon scoparius / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 456-464, 2018.
Article
在 En
| WPRIM
| ID: wpr-773596
Responsible library:
WPRO
ABSTRACT
Nine new ent-kaurane diterpenoids, named scopariusols L-T (1-9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC value of 0.6 μmol·L.
Key words
全文:
1
索引:
WPRIM
主要主题:
Pharmacology
/
Drug Screening Assays, Antitumor
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Chemistry
/
Lipopolysaccharides
/
Crystallography, X-Ray
/
HL-60 Cells
/
Nuclear Magnetic Resonance, Biomolecular
/
Isodon
限制:
Animals
/
Humans
语言:
En
期刊:
Chinese Journal of Natural Medicines (English Ed.)
年:
2018
类型:
Article