Jatrogricaine A: a new diterpenoid with a 5/6/6/4 carbon ring system from the stems of Jatropha podagrica / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 298-302, 2019.
Article
在 En
| WPRIM
| ID: wpr-776883
Responsible library:
WPRO
ABSTRACT
Jatrogricaine A (1), a new diterpenoid possessing a 5/6/6/4 carbon ring system, together with eight known diterpenoids (2-9) were isolated from the stems of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods and the absolute configuration of 1 was determined by single crystal X-ray diffraction analysis. All compounds were evaluated for their anti-inflammatory activities in vitro, and compound 3 showed significant inhibitory effects against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells with an IC of 13.44 ± 0.28 μmol·L, being comparable to the positive control, quercetin (IC 17.00 ± 2.10 μmol·L).
Key words
全文:
1
索引:
WPRIM
主要主题:
Pharmacology
/
Carbon
/
Plant Extracts
/
Molecular Structure
/
Chemistry
/
Lipopolysaccharides
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Plant Stems
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Inhibitory Concentration 50
/
Jatropha
/
Diterpenes
限制:
Animals
语言:
En
期刊:
Chinese Journal of Natural Medicines (English Ed.)
年:
2019
类型:
Article