ABSTRACT
BACKGROUND:
The application of coronary
stents, especially
drug-eluting stents (DESs), has made
percutaneous coronary intervention (PCI) one of important
therapeutic methods for CHD. DES has reduced the in-
stent restenosis to 5%–9% and signifi cantly improved the long-term
prognosis of
patients with CHD. The study aimed to investigate the long-term
efficacy and
safety of domestic
drug-eluting stents (DESs) in
patients with
acute coronary syndrome (ACS).
METHODS:
All
patients with ACS
who had undergone successful
percutaneous coronary intervention (PCI) in the First Affiliated
Hospital of Zhengzhou
University from July 2009 to December 2010 were included in this study.
Patients were excluded from the study if they were implanted with bare
metal stents or different
stents (domestic and imported DESs) simultaneously. The included
patients were divided into two groups according to different
stents implanted domestic DESs and imported DESs.
RESULTS:
In the 1683
patients of this study, 1558 (92.6%)
patients were folowed up successfuly for an average of (29.1±5.9) months. 130 (8.3%)
patients had major adverse cardiovascular events (MACEs), including
cardiac death in 32 (2.1%)
patients, recurrent
myocardial infarction in 16 (1%), and revascularization in 94 (6%). The rates of
cardiac death, recurrent
myocardial infarction, revascularization, in-
stent restenosis,
stent thrombosis and other MACEs were not significantly different between the two groups (allP>0.05). Multivarite
logistic regression revealed that
diabetes mellitus (OR=1.75, 95%CI 1.09–2.82,P=0.021), vascular numbers of PCI (OR=2.16, 95%CI 1.22–3.83, P=0.09) and PCI with left main lesion (OR=9.47, 95%CI 2.96–30.26,P=0.01) were independent
prognostic factors of MACEs. The Kaplan-Meier
method revealed that there was no significant difference in
cumulative survival rates and
survival rates free from clinical events between the two groups (allP>0.05).
CONCLUSIONS:
The
incidences of clinical events and
cumulative survival rates are not statistically different between domestic DESs and imported DESs. Domestic DES is effective and safe in the
treatment of
patients with ACS.