Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology / 药学实践杂志
Journal of Pharmaceutical Practice
; (6): 411-414,432, 2017.
Article
在 Zh
| WPRIM
| ID: wpr-790782
Responsible library:
WPRO
ABSTRACT
Objective To prepare Herba Cistanche enteric release microspheres, optimize the preparation process and study the releasing characteristics of microspheres in vitro.Methods Ion gelatin-oven drying method was used to prepare Herba Cistanche enteric microspheres.The preparation process was optimized with the aid of a Box-Behnken design.Results The optimal preparation condition was 36.33 mg/ml of sodium alginate, 10.82 mg/ml of calcium chloride and 10.93 mg/ml of chitosan.Conclusion This technology is repeatable and feasible.The microspheres have high entrapment efficiency and good sustained release characteristics.