ABSTRACT
OBJECTIVE:
To discuss expression of
antiphospholipid antibody subtypes in primary glomerular
diseases.
METHODS:
All1021 cases
who were admitted to our center between June 2015 and July 2017 in
Kidney Disease Center, First Affiliated
Hospital,College of
Medicine, Zhejiang Universityhad renal
biopsy in our center and they were praved to have primary glomerular
diseases(303 cases of
membranous nephropathy, 483 cases of
IgA nephropathy, 76 cases of mesangial proliferative
glomerulonephritis, 119 cases of
minimal change nephropathy and 40 cases of
focal segmental glomerulosclerosis). The levels of anti-
cardiolipin(ACL) antibody subtypes(
IgG,
IgM and
IgA)and anti-β2
glycoprotein 1(β2 GP1) antibody subtypes(
IgG,
IgM and
IgA) were measured and compared.
RESULTS:
The positive rate of APA in
membranous nephropathy group was highest(17.5%) and in
minimal change nephropathy was lowest group(11.8%), but there were no significant differences among the groups. The positive rates of ACL in
IgA nephropathy and mesangial proliferative
glomerulonephritis were 11.4% and 14.5% respectively, which were significantly higher than those of anti-β2 GP1 antibody(P< 0.001, P = 0.009 respectively). The positive rate of anti-β2 GP1 antibody in
membranous nephropathy group was 11.2%,significantly higher than that in the other four groups. The positive rate of ACL-
IgM in mesangial proliferative
glomerulonephritis group was 13.2%, which was significantly higher than that in the other four groups(P< 0.05). The positive rate of ACL-
IgA in
IgA nephropathy group was 5.8%, which was significantly higher than the other four groups, and there was no statistical difference(P<0.05).
CONCLUSION:
Antiphospholipid antibody is positive in
patients with primary glomerular
diseases, and the positive rate of its subtypes varies among the different pathological types of
glomerulonephritis, which can be helpful to
differential diagnosis and
treatment of the
disease.