Correlation between the Xba I polymorphism of apoB gene and serum lipid profiles in Li ethnic group
Asian Pacific Journal of Tropical Medicine
; (12): 63-66, 2014.
Article
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| WPRIM
| ID: wpr-819729
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To study correlation between the Xba I polymorphism of apoB gene and plasma lipid profiles in Li ethnic group.@*METHODS@#Total 151 cases of healthy Li people were recruited randomly by cluster sampling and 200 Han people were recruited as control; blood was drawn to analyze Xba I polymorphism distribution of apoB gene and serum lipid levels.@*RESULTS@#There were lower serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels in serum of Li people; while, high density lipoprotein cholesterol (HDL-C), X-/X+ genotype and X+ allele frequencies exhibited higher levels than Han people. Interestingly, HDL-C level was reduced, while LDL-C level was enhanced in subjects carrying heterozygous (X-/X+) genotype compared to homozygous (X-/X-) genotype. Additionally, there were no difference in serum level of triglyceride, TC, apoprotein A (apo A) and apoprotein B (apo B) between Li and Han people, the same results were showed between X-/X+ and X-/X- genotype carriers.@*CONCLUSIONS@#Xba I polymorphism of apoB gene is correlated to the profiles of serum lipid level, X-/X+ genotype carriers are phenotyped with higher LDL-C level and lower level of HDL-C in Li ethnic group.
Key words
全文:
1
索引:
WPRIM
主要主题:
Apolipoproteins B
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Blood
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Deoxyribonucleases, Type II Site-Specific
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Ethnicity
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Chi-Square Distribution
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Analysis of Variance
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Polymorphism, Single Nucleotide
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Asian People
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Gene Frequency
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Genetics
限制:
Humans
语言:
En
期刊:
Asian Pacific Journal of Tropical Medicine
年:
2014
类型:
Article