Bioinformatics analysis of breast cancer bone metastasis related gene-CXCR4

ABSTRACT

OBJECTIVE@#To analyze breast cancer bone metastasis related gene-CXCR4.@*METHODS@#This research screened breast cancer bone metastasis related genes by high-flux gene chip.@*RESULTS@#It was found that the expressions of 396 genes were different including 165 up-regulations and 231 down-regulations. The expression of chemokine receptor CXCR4 was obviously up-regulated in the tissue with breast cancer bone metastasis. Compared with the tissue without bone metastasis, there was significant difference, which indicated that CXCR4 played a vital role in breast cancer bone metastasis.@*CONCLUSIONS@#The bioinformatics analysis of CXCR4 can provide a certain basis for the occurrence and diagnosis of breast cancer bone metastasis, target gene therapy and evaluation of prognosis.