Polymorphisms in Apoptosis-Related Genes and TP53 Mutations in Non-Small Cell Lung Cancer
Journal of Korean Medical Science
; : 1527-1530, 2011.
Article
在 En
| WPRIM
| ID: wpr-82219
Responsible library:
WPRO
ABSTRACT
Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby affecting the occurrence of TP53 mutations in lung cancer. We investigated the relationship between potentially functional polymorphisms of apoptosis-related genes and TP53 mutations in non-small cell lung cancer (NSCLC). Twenty-seven single nucleotide polymorphisms in 20 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay in 173 NSCLCs and the associations with TP53 mutations in the entire coding exons (exons 2-11), including splicing sites of the gene, were analyzed. None of the 27 polymorphisms was significantly associated with the occurrence of TP53 mutations. This suggests that apoptosis-related genes may not play an important role in the occurrence of TP53 mutations in lung cancer.
Key words
全文:
1
索引:
WPRIM
主要主题:
DNA Mutational Analysis
/
Genes, p53
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Apoptosis
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Carcinoma, Non-Small-Cell Lung
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Genetic Predisposition to Disease
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Polymorphism, Single Nucleotide
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Genotype
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Lung Neoplasms
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Mutation
限制:
Female
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Humans
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Male
语言:
En
期刊:
Journal of Korean Medical Science
年:
2011
类型:
Article