Hyperbaric Oxygen Treatment Improves Hearing Level Attenuating TLR4/NF-κB Mediated Inflammation in Sudden Sensorineural Hearing Loss Patients / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 331-337, 2020.
Article
在 En
| WPRIM
| ID: wpr-829008
Responsible library:
WPRO
ABSTRACT
Objective@#Hyperbaric oxygen treatment (HBOT) has demonstrated efficacy in improving hearing levels of patients with idiopathic sudden sensorineural hearing loss (ISSHL); however, the underlying mechanisms are not well understood. HBOT alleviates the inflammatory response, which is mediated by Toll-like receptor (TLR) 4 and nuclear factor (NF)-κB. In this study we investigated whether HBOT attenuates inflammation in ISHHL patients alteration of TLR4 and NF-κB expression.@*Methods@#ISHHL patients ( = 120) and healthy control subjects ( = 20) were enrolled in this study. Patients were randomly divided into medicine group treated with medicine only ( = 60) and HBO group receiving both HBOT and medicine ( = 60). Audiometric testing was performed pre- and post-treatment. TLR4, NF-кB, and TNF-α expression in peripheral blood of ISSHL patients and healthy control subjects was assessed by ELISA before and after treatment.@*Results@#TLR4, NF-κB, and TNF-α levels were upregulated in ISSHL patients relative to healthy control subjects; the levels were decreased following treatment and were lower in the HBO group than that in the medicine group post-treatment ( < 0.05 and < 0.01).@*Conclusion@#HBOT alleviates hearing loss in ISSHL patients by suppressing the inflammatory response induced by TLR4 and NF-κB signaling.
Key words
全文:
1
索引:
WPRIM
主要主题:
Therapeutics
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China
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Hearing Loss, Sudden
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NF-kappa B p50 Subunit
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Toll-Like Receptor 4
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Genetics
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Hearing Loss, Sensorineural
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Hyperbaric Oxygenation
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Inflammation
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Metabolism
限制:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
国家/地区名称主题:
Asia
语言:
En
期刊:
Biomedical and Environmental Sciences
年:
2020
类型:
Article