Study on mixing uniformity of powder based on raw material powder of Qingrun Pill design technology and near infrared spectroscopy / 中草药

ABSTRACT

Objective: Using Qingrun Pill as model drug, the raw material powder of Qingrun Pill with uniform mixture was prepared. The rapid analysis method was used to evaluate the mixing uniformity of Qingrun Pill raw materials. Methods: Based on the particle design technology, the raw material powder of Qingrun Pill was prepared, the core-shell particles were established with the particle size as the index, and the mixing uniformity of the raw material powder of Qingrun Pill was analyzed with the standard deviation of moving block as the index by near infrared spectroscopy. Finally, it was verified by HPLC. Results: According to the particle design technology, the raw material powder of Qingrun Pill was designed. Shell particles: Rheum officinale and other materials; Nuclear particles: Scutellaria baicalensis and other materials; The particle size (d0.9) of shell particles at ultrafine grinding for 12 min was about 5 μm, and that of nuclear particles at ultrafine grinding for 6 min was about 130 μm. The ratio of nuclear particles to shell particles was more than 10:1, which met the requirements of particle design. Near-infrared spectroscopy showed that shell particles were ultrafine comminuted for 12 min, and then the nuclear particles were mixed evenly for 6 min. Conclusion: In this study, Qingrun Pill powder was prepared based on particle design technology, and the mixing uniformity of powder was evaluated by near infrared spectroscopy. This method is simple and feasible, real-time, and without destroying the sample.