ABSTRACT
Objective:
To study the antitumor constituents from Chloranthus fortunei.
Methods:
Various chromatographic
techniques and spectroscopic
methods were applied to investigate the chemical constituents from C. fortunei, and some of the compounds were screened for their antitumor activities by MTT
method.
Results:
Sixteen compounds were obtained from the whole
plants of C. fortunei and identified as
rosmarinic acid (1), 2’-hydroxy-4,3’,4’,6’-tetramethoxychalcone (2), flavokawain A (3), cycloshizukaol A (4), atractylenolide III (5), 4β-hydroxy-8,12-epoxyeudesma-7,11-diene-1,6-dione (6), (8α)-6,8-dihydroxycadina-7 (11),10 (15)-dien-12-oic
acid γ-
lactone (7), curcolonol (8), 11-hydroxyldrim-8,12-en-14-oic
acid (9), friedelin (10), isovanillic
acid (11), 6β-hydroxystigmast-4-en-3-one (12), 3,4-dihydroxybenzoic
acid (13),
shikimic acid (14), scopolin (15) and N-acetyltyramine 1-O-β-D-
glucoside (16). Compounds 4 and 5 showed weak cytotoxicity with
IC50 ranged from 46 to 85 μmol/L.
Conclusion:
Compounds 2, 10, 11, and 13-15 are obtained from the genus Chloranthus for the first
time and compounds 1-3 and 6-16 are isolated from C. fortunei for the first
time. Some
sesquiterpenoids from C. fortunei exhibited weak antitumor activities.
