Research progress on pharmacological effects and mechanisms of flavonoids from Scutellaria baicalensis based on aging hypotheses / 中草药

ABSTRACT

Baicalin, baicalein, wogonoside, and wogonin are major flavonoids of Scutellaria baicalensis, which have been reported to possess various pharmacological effects such as anti-oxidation, immunomodulation, mitochondrial protection, telomerase inhibition, and anti-inflammatory activities. Recently, researches on their anti-aging activity have also gradually increased. Therefore, combining with kinds of aging hypotheses, e.g. the free radical aging hypothesis, immunosenescence aging hypothesis, spleen-kidney aging hypothesis of Chinese medicine, the mitochondrial aging hypothesis, the telomere hypothesis of cellular aging, inflamm-aging, we focus on the related pharmacological properties and mechanisms of these four flavonoids and make a review, aiming to provide a theoretical basis for the anti-aging research of flavonoids in S. baicalensis.