Research progress on anti-metastatic mechanism of resveratrol and its metabolites and analogues in cancer cells / 中草药

ABSTRACT

The epithelial-mesenchymal transition (EMT) effect, cell migration, and invasion ability of cancer cells play important roles in the process of cancer metastasis. Resveratrol is a natural polyphenol found in grapes, berries, and peanut skins. Many experimental studies have shown that resveratrol and its metabolites and analogs have multiple targeting anti-cancer effects. The aim of this study is to provide resveratrol and its metabolites and analogues to inhibit the potential for cancer metastasis by influencing many signaling pathways associated with EMT, cancer migration and different organ invasion. We found that resveratrol’s metabolites and analogues can inhibit the EMT process by affecting the role of multiple signaling pathways, inhibiting the metastasis and erosion of cancer through the literature review.