A new 8-O-4′-neolignan from stem barks of Lindera caudata and its cytotoxicity / 中草药

ABSTRACT

Objective: To study the chemical constituents in the stem barks of Lindera caudata. Methods: The chemical constituents from the stem barks of L. caudata were isolated by column chromatographic methods of silica gel, MCI-Gel resin, Sephadex LH-20, and high performance liquid chromatography. The structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The cytotoxicity of this compound for NB4, A549, SHSY5Y, PC3, and MCF7 cells line was also observed by using the MTT method. Results: A 8-O-4′-neolignan, caudatalignan A (1) was isolated from this plants. Conclusion: Compound 1 is a new compound and displays the cytotoxicity against NB4 and SHSY5Y cells with IC50 values of 4.2 and 5.0 μmol/L, respectively.