Research progress on pharmacological action of riluzole / 中国药学杂志

ABSTRACT

Riluzole is a benzothiazole compounds, and it is the only drug approved by FDA for the treatment of amyotrophic lateral sclerosis. By adjusting the concentration of glutamic acid and interfering with ion channels, riluzole has a wide range of pharmacology action, such as, regulating glutamate concentration, neuroprotective, cardioprotective, anti-depressants, anti-anxiety, analgesic and so on. In this paper, the pharmacological action of riluzole is summarized, aiming at providing help for its research and application.