Effect of metaraminol on maintaining hemodynamics during anaesthesia: a meta-analysis / 中国药学杂志

ABSTRACT

OBJECTIVE: To evaluate the effectiveness and safety of metaraminol in maintaining hemodynamics during anaesthesia. METHODS: Cochrane library, Pubmed, Embase, CBM, CNKI, VIP and Wanfang Database were searched. Randomized controlled trials (RCT) of metaraminol vs placebo or ephedrine in maintaining hemodynamics during anaesthesia were selected, and quality evaluation and Meta analysis were performed. RESULTS Ten RCTs were selected. The efficacy of metaraminol in maintaining hemodynamics during anaesthesia was better than placebo, it showed significant differences between the two groups in the incidence of hypotension [RR 0.23, 95%CI(0.12, 0.41), P < 0.01] and in the reduction of SAP [MD-10.22, 95% CI(-12.55, -7.89), P < 0.01], but no significant difference in the change of heart rate [MD 3.35, 95% CI (-11.88, 18.58), P=0.67]. There were no significant difference between metaraminol and ephedrine in the incidence of hypotension [RR 0.79, 95%CI(0.45, 1.39), P=0.42], the reduction of SAP [MD 1.47, 95%CI(-0.39, 3.34), P=0.12] and the change of heart rate [MD-12.11, 95% CI(-34.56, 10.34), P=0.29]. CONCLUSION The effect of metaraminol on maintaining hemodynamics during anaesthesia is equivalent to that of ephedrine; meanwhile metaraminol has fewer adverse effects than ephedrine.