ABSTRACT
Objective:
To evaluate the
clinical efficacy of modified Baihe-Gujin Decoction combined with routine
chemotherapy for the
elderly patients with primary treated
pulmonary tuberculosis and
lung-
kidney yin deficiency.
Methods:
A total of 94
patients who met the inclusion criteria in our
hospital from January 2016 to January 2018 were selected and divided into 2 groups according to the random number table
method, with 47
patients in each group. The
control group was treated with the routine
chemotherapy regimen of 2HRZE/4HR (H
isoniazid, R
rifampicin, Z
pyrazinamide, E ethambutanol), the
observation group was treated with Baihe-Gujin Decoction on the basis of the routine
chemotherapy. Both groups were treated continuously for 6 months. The
sputum negative rate was observed 2, 5 and 6 months
after treatment, The closure of cavity shadows was observed by
chest CT. The content of
IL-6 and IFN-γ-inducible
protein-10 were detected by double antibody sandwich
ELISA.
T cell subsets was detected by
flow cytometry. And the
clinical efficacy was evaluated.
Results:
The total effective rate was 87.2% (41/47) in the
observation group and 61.7% (29/47) in the
control group, and the difference between the two groups was statistically significant ( χ2=8.050, P=0.004).
After treatment, the TCM
syndrome score of the
observation group was significantly lower than that of the
control group ( t=5.698, P<0.01). At the end of 6 months
after treatment, the
sputum negative rate in the
observation group was significantly higher than that of the
control group ( t=5.317, P=0.021), the effective rate of cavity shadow closure (95.7% with 45/47 vs. 83.0% with 39/47) in the
observation group was significantly higher than that of the
control group ( χ2=4.029, P=0.044).
After treatment, the levels of CD3 +, CD4 + and CD4 +/CD8 + in the
observation group were all significantly higher than those in the
control group ( t values were 2.107, 3.571 and 2.351, respectively, all Ps<0.05), and the levels of CD8 + in the
observation group were all significantly lower than those in the
control group ( t=2.711, P=0.005). The levels of
IL-6 and IFN-γ-induced
protein-10 in the
observation group were significantly lower than those in the
control group ( t values were 2.517 and 2.890, respectively, all Ps<0.05).
Conclusions:
The modified Baihe-Gujin Decoction combined with routine
chemotherapy can improve the
immunity of the
elderly patients with primary treated
pulmonary tuberculosis with
lung-
kidney yin deficiency, and improve the
clinical efficacy.