Effect of estradiol valerate combined with dydrogesterone on prevention of intrauterine adhesions after abortion and its influence on sex hormone level / 中国基层医药

ABSTRACT

Objective:To investigate the effect of estradiol valerate combined with dydrogesterone on prevention of uterine adhesions after abortion and its influence on sex hormone level.Methods:From January 2018 to October 2019, 142 patients who underwent artificial abortion in the First People's Hospital of Jiande were divided into observation group(71 cases) and control group(71 cases) according to the random digital table mathod.The control group was given postoperative treatment to promote uterine contraction and congestion, and the observation group was given estradiol valerate tablets combined with dydrogesterone tablets on the basis of the control group.The course of treatment in both two groups was 3 months.The bleeding time, bleeding volume and menstrual rehydration time, menstrual volume after operation, the change of serum sex hormone level preoperation and postoperative 3 months, and the occurrence of intrauterine adhesions at 12 months after operation were compared between the two groups.Results:The bleeding time[(4.35±0.97)d] and menstrual recovery time[(24.83±1.43)d] in the observation group were shorter than those in the control group[(5.67±1.14)d and (28.79±1.78)d], and the bleeding amount[(42.54±8.97)mL]in the observation group was less than that in the control group[(53.67±6.81)mL], the differences were statistically significant between the two groups( t=7.431, 14.614, 8.327, all P<0.05). The patients with normal amount of menstruation in the observation group (94.37%) was more than that in the control group(81.69%)(χ 2=5.413, P<0.05). The serum E2 level[(167.39±27.84)ng/L] in the observation group was higher than that in the control group[(108.92±21.01)ng/L], while FSH[(17.83±3.27)IU/L] and LH[(28.98±7.63)IU/L] in the observation group were lower than those in the control group[(26.54±4.58)IU/L and (49.83±13.54)IU/L], the differences were statistically significant between the two groups( t=14.126, 13.042, 11.304, all P<0.05). The incidence of intrauterine adhesions in the observation group(2.82%) was lower than that in the control group(14.08%)(χ 2=5.826, P<0.05). Conclusion:Estradiol valerate combined with dydrogesterone has good effect on the prevention of postoperative uterine adhesions, which can effectively reduce the amount of postoperative bleeding, reduce the amount of postoperative uterine adhesions, improve the amount of menstruation and improve the level of sexual hormones of patients.It is worthy of clinical reference.