ABSTRACT
Objective:
To investigate the correlation between urinary 8-oxo-7, 8-dihydroguanosine(8-oxo-Gsn)and physical function in
community-dwelling
elderly people.
Methods:
A total of 210
community-dwelling
elderly people
aged 75 years and over were enrolled in this
cross-sectional analysis.According to the scores of short
physical performance battery(SPPB), subjects were divided into three groups the high performance group(summary score 10-12), the intermediate performance group(summary score 7-9)and the low performance group(summary score 0-6). All participants received a comprehensive
geriatric assessment.Urinary 8-oxo-dGsn,
serum high-
sensitivity C-reactive protein(
hs-CRP)and
white blood cell count were measured.The correlation between urinary 8-oxo-Gsn and physical function was analyzed by using Pearson correlation
analysis and the ordered
Logistic regression model.
Results:
The scores of
activities of daily living(
ADL), instrumental
activities of daily living(IADL),
grip strength and
gait speed were lower in the low performance group than in the other two groups( H=47.002, 110.902, F=11.962, 235.952, all P<0.001). Levels of urinary 8-oxo-Gsn and
serum hs-CRP were higher in the low performance group than in the other two groups( F=23.780 and 13.259, both P<0.001). There was no significant difference in levels of urinary 8-oxo-dGsn or
white blood cell count between the three groups(both P>0.05). Urinary 8-oxo-Gsn was negatively correlated with
gait speed,
grip strength and SPPB score( r=-0.559, -0.302 and-0.450, all P<0.001)and was positively correlated with the
time of five-times-sit-to-stand test( r=0.290, P<0.001). Adjusting for age,
gender and Charlson
comorbidity index, the ordered
Logistic regression analysis showed that elevated levels of urinary 8-oxo-Gsn( OR=1.38, 95% CI 1.06-1.77, P<0.05)and
hs-CRP( OR=1.23, 95% CI 1.04-1.48, P<0.05)decreased physical function.
Conclusions:
Urinary 8-oxo-Gsn is independently associated with the decline of physical function in
community-dwelling
elderly adults, suggesting that the
oxidative stress level is increased in the
elderly with poor physical function.