ABSTRACT
Objective:
To systematically
review and compare the
efficacy of intranasal
dexmedetomidine versus oral
midazolam for
premedication in the pediatric
patients.
Methods:
PubMed, EMbase and Cochrane
library were searched for all randomized controlled trials involving the
efficacy of intranasal
dexmedetomidine versus oral
midazolam for
premedication in the pediatric
patients from inception to August 2019, with an English
language restriction.
Evaluation indexes included
efficacy of preoperative sedation, acceptance of
face mask for
anesthesia, postoperative requirement for rescue
analgesia,
incidence of agitation during emergence and postoperative recovery
time.The quality of the included trials was assessed according to the relevant criteria recommended in Cochrane
Handbook for Systematic Reviews of Interventions Version 5.0.1.
Meta-analysis was conducted using the Cochrane Collaboration′s
Review Manager 5.3
software.
Results:
Ten randomized controlled trials involving 720 pediatric
patients were included.Compared with oral
midazolam group, the
efficacy of preoperative sedation was better, the requirement for postoperative rescue
analgesia was decreased ( P<0.01), and no significant differences were found in acceptance of
face mask for
anesthesia,
incidence of agitation during emergence, and postoperative recovery
time in intranasal
dexmedetomidine group ( P>0.05).
Conclusion:
Intranasal
dexmedetomidine provides better
efficacy than oral
midazolam when used for
premedication in the pediatric
patients.
