ABSTRACT
Objective:
This study aimed to evaluate the accuracy of a portable REF-XT01
uric acid meter in measuring
blood uric acid concentration, and to determine whether the results of the
uric acid meter could be used to guide the
adjustment of
uric acid-lowering
drugs.
Methods:
1 551 subjects were enrolled from the
Gout Clinical Medical Center of the Affiliated
Hospital of Qingdao
University. The
fasting venous
blood was collected and the
serum uric acid was measured by an automatic biochemical analyzer. Meanwhile, the
capillary blood uric acid was measured by fingertip
puncture using the REF-XT01
uric acid meter.
Linear regression, intra-group correlation coefficient(ICC), and Bland-Altman plots were used to analyze the
uric acid concentration correlation between the biochemical analyzer(sUA BA)and the
uric acid meter(sUA UM). The
receiver operating characteristic curve(
ROC curve)was conducted to evaluate whether sUA UM can be used as a reference for the
gout patients to take
uric acid-lowering
drugs.
Results:
The
regression analysis showed correlation between sUA BA and sUA UM, with the regression formula Y=0.875X+ 39.525( r=0.84, P<0.01)and the ICC was 0.829(95% CI 0.814-0.844, P<0.01). The Bland-Altman diagram showed a good consistence(the absolute deviation was-143.4-114.5 μmol/L, mean deviation was -14.4 μmol/L)between sUA BA and sUA UM. The
sensitivity was 96.61%,
specificity was 48.81%, and the area under the
ROC curve(
AUC)was 0.926( P<0.01)when 300 μmol/L was defined as the
detection threshold of the
uric acid meter, the
sensitivity was 90.98%,
specificity was 66.78%, and the area under the
ROC curve(
AUC)was 0.914( P<0.01)when 360 μmol/L was defined as the
detection threshold of the
uric acid meter.
Conclusion:
REF-XT01
uric acid meter is applicable for the
adjustment of
uric acid-lowering
drugs for the
gout patients, because of its high accuracy for the
detection of
uric acid.