Identification of TCF3-ZNF384 fusion by transcriptome sequencing in B cell acute lymphoblastic leukemia and its laboratory and clinical characteristics / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 351-354, 2021.
Article
在 Zh
| WPRIM
| ID: wpr-879584
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To detect fusion gene with pathological significance in a patient with refractory and relapsed acute B cell lymphoblastic leukemia (B-ALL) and to explore its laboratory and clinical characteristics.@*METHODS@#Transcriptome sequencing was used to detect potential fusion transcripts. Other laboratory results and clinical data of the patient were also analyzed.@*RESULTS@#The patient was found to harbor TCF3 exon 17-ZNF384 exon 7 in-frame fusion transcript. The minimal residual disease (MRD) has remained positive after multiple chemotherapy protocols including CD19-, CD22- targeted chimeric antigen receptor T cells immunotherapy. The patient eventually achieved complete remission and sustained MRD negativity after allogeneic hemopoietic stem cell transplantation (allo-HSCT).@*CONCLUSION@#Transcriptome sequencing can effectively detect potential fusion genes with clinical significance in leukemia. TCF3-ZNF384 positive B-ALL has unique laboratory and clinical characteristics, may not well respond to chemotherapy and immunotherapy, and is more likely to relapse. Timely allo-HSCT treatment may help such patients to achieve long-term disease-free survival. TCF3-ZNF384 positive B-ALL is not uncommon in pediatric patients but has not been effectively identified.
全文:
1
索引:
WPRIM
主要主题:
B-Lymphocytes
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Trans-Activators
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Hematopoietic Stem Cell Transplantation
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Basic Helix-Loop-Helix Transcription Factors
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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Transcriptome
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Laboratories
研究类型:
Diagnostic_studies
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Guideline
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Prognostic_studies
限制:
Child
/
Humans
语言:
Zh
期刊:
Chinese Journal of Medical Genetics
年:
2021
类型:
Article