Protective effect of iridoid glycosides of radix scrophulariae on endoplasmic reticulum stress induced by oxygen-glucose deprivation and reperfusion / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 705-713, 2020.
Article
在 Zh
| WPRIM
| ID: wpr-879932
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the regulatory effect of iridoid glycoside of radix scrophulariae (IGRS) on endoplasmic reticulum stress induced by oxygen-glucose deprivation and reperfusion @*METHODS@#Rat pheochromocytoma PC12 cells were pretreated with IGRS (50, 100, 200 μg/mL) for 24h, and the @*RESULTS@#The damage caused by OGD/R to PC12 cells was significantly reduced by IGRS, with significant effect on increasing survival rate and reducing LDH release (all @*CONCLUSIONS@#IGRS has neuroprotective effect, which may alleviate cerebral ischemia-reperfusion injury by regulating SERCA2, maintaining calcium balance, and inhibiting endoplasmic reticulum stress-mediated apoptosis.
Key words
全文:
1
索引:
WPRIM
主要主题:
Oxygen
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Snails
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In Vitro Techniques
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Reperfusion
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Reperfusion Injury
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Down-Regulation
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Cell Survival
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PC12 Cells
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Iridoid Glycosides
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Endoplasmic Reticulum Stress
限制:
Animals
语言:
Zh
期刊:
Journal of Zhejiang University. Medical sciences
年:
2020
类型:
Article