ABSTRACT
Objective:
To understand the relationship between the
disease condition of
patients with
coal-burning-borne endemic
arsenic poisoning (abbreviated as
coal-burning-borne
arsenic poisoning) and
serum lipid metabolism indicators.
Methods:
Using a
case-control study method, in the
coal-burning-borne
arsenic poisoning village of Yuzhang Town, Qianxinan Prefecture, Guizhou Province, 204
patients with
arsenic poisoning diagnosed according to the standard of "
Diagnosis of Endemic
Arsenicosis" (WS/T 211-2015) were included in case group, including 87
males and 117
females,
aged(53.37 ± 8.06) years old; and they were divided into mild
arsenic poisoning group (71 cases), moderate
arsenic poisoning group (59 cases) and severe
arsenic poisoning group (74 cases) according to the clinical grading. Another 63 residents were selected into
control group in a non-
arsenic-exposed village about 12 km away from the diseased village, including 23
males and 40
females,
aged (53.78 ± 9.10) years old. A
face-to-
face questionnaire survey was conducted for each group of people, including basic information such as general demographic characteristics,
smoking status, and
drinking status;
fasting peripheral
blood was collected, and an automatic biochemical analyzer was used to detect
serum total
cholesterol (TC) and
triglyceride (TG),
low-density lipoprotein cholesterol (LDL-C), and
high-density lipoprotein cholesterol (HDL-C) levels.
Results:
There were significant differences of
serum TC [(4.94 ± 1.00), (5.00 ± 0.99), (5.27 ± 0.94), (5.57 ± 1.07) mmol/L], TG [(2.17 ± 0.90), (2.25 ± 1.31), (2.66 ± 1.43), (2.78 ± 1.40) mmol/L], LDL-C [(2.51 ± 0.79), (2.74 ± 0.64), (2.97 ± 0.66), (3.15 ± 0.80) mmol/L], and HDL-C levels [(1.57 ± 0.55), (1.42 ± 0.43), (1.36 ± 0.42), (1.30 ± 0.38) mmol/L] in
control group, mild, moderate and severe
arsenic poisoning groups ( F = 5.83, 3.64, 9.72, 4.41, P < 0.01 or < 0.05). Among them, the
serum TC level in severe
arsenic poisoning group,
serum TG and LDL-C levels in moderate and severe
arsenic poisoning groups were significantly higher than those in
control group ( P < 0.05); the
serum HDL-C level in moderate and severe
arsenic poisoning groups were lower than that in
control group ( P < 0.05); the
serum TC, TG and LDL-C levels in severe
arsenic poisoning group were significantly higher than those in mild
arsenic poisoning group ( P < 0.05). After linear trend test,
serum TC, TG and LDL-C levels all showed an upward trend with the degree of
arsenic poisoning ( Ftrend = 15.77, 10.14, 29.15, P < 0.05), and
serum HDL-C level showed a downward trend with the degree of
arsenic poisoning ( Ftrend = 12.75, P < 0.05). There were significant differences in the abnormal rates of
serum TC, TG and LDL-C levels among
control group and mild, moderate and severe
arsenic poisoning groups (χ 2 = 21.16, 16.60, 8.29, P < 0.01 or < 0.05). Among them, the
serum TC and TG levels abnormal rates in moderate and severe
arsenic poisoning groups and
serum LDL-C level abnormal rate in severe
arsenic poisoning group were higher than those in
control group ( P < 0.05), the
serum TC, TG and LDL-C levels abnormal rates in severe
arsenic poisoning group were higher than those in mild
arsenic poisoning group ( P < 0.05). There was no significant difference of the
serum HDL-C level abnormal rate among four groups (χ 2 = 2.11 , P > 0.05). The results of trend chisquare
analysis showed that the abnormal rates of
serum TC, TG and LDL-C levels presented an increasing trend with the degree of
arsenic poisoning (χ 2trend = 19.90, 15.25, 7.63, P<0.05). The results of
logistic regression analysis showed that the
risk of abnormal
serum TC level in
patients with severe
arsenic poisoning was 2.90 times that in
control group [
odds ratio ( OR) = 2.90, 95%
confidence interval ( CI) 1.43 - 5.91], and the
risk of abnormal
serum LDL-C level in
patients with severe
arsenic poisoning was 2.87 times that in
control group ( OR = 2.87, 95% CI 1.22 - 6.71).
Conclusion:
There is a correlation between the
disease condition of
patients with
coal-burning-borne
arsenic poisoning and their
dyslipidemia.